Awake versus Anesthetized : Layer - Specific Sensory Processing in Visual Cortex and 1 Functional Connectivity between Cortical Areas 2 3 Running Head : Anesthetics Disrupt Sensory Processing

Awake versus Anesthetized: Layer-Specific Sensory Processing in Visual Cortex and 1 Functional Connectivity between Cortical Areas 2 3 Running Head: Anesthetics Disrupt Sensory Processing 4 5 Kristin K. Sellers, Davis V. Bennett, Axel Hutt , James H. Williams, and Flavio Frohlich 6 7 1 Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill NC 27599 8 2 Neurobiology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill NC 27599 9 3 INRIA CR Nancy – Grand Est, Team Neurosys, Villers-les-Nancy, France 10 4 Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill NC 11 27599 12 5 Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel 13 Hill NC 27599 14 6 Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill 15 NC 27599 16 7 Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill NC 27599 17 18 Correspondence should be addressed to Flavio Frohlich, 115 Mason Farm Rd. NRB 4109F, 19 Chapel Hill, NC. 27599. Email: [email protected]. Phone: 919.966.4584 Fax: 20 919.966.0370 21 22 23 Authorship Statement: KKS, DVB, and FF designed the experiments, KKS, DVB, and FF 24 performed the experiments, KKS, DVB, AH, and FF analyzed the data, and KKS, JHW, FF 25 wrote the paper. 26 27 The authors declare no competing financial interests. 28 29 30 31 Articles in PresS. J Neurophysiol (April 1, 2015). doi:10.1152/jn.00923.2014